Download Amobarbital Effects and Lateralized Brain Function: The Wada by David W. Loring, Kimford J. Meador, Gregory P. Lee, Don W. PDF

By David W. Loring, Kimford J. Meador, Gregory P. Lee, Don W. King

The intracarotid amobarbital (or Amytal) process is usually often called the Wada try in tribute to Juhn Wada, the general practitioner who devised the strategy and played the 1st uncomplicated animal examine and medical reviews with this technique. Wada checking out has develop into a vital part of the pre­ operative overview for epilepsy surgical procedure. curiously, notwithstanding, Wada at first constructed this technique as a strategy to evaluate language dominance in psychiatric sufferers so that electroconvulsant remedy might be utilized unilaterally to the non-dominant hemisphere. Epilepsy surgical procedure has matured as a plausible therapy for intractable seizures and is not any longer confmed to a couple significant universities and scientific institutes. but, as is more and more transparent by way of analyzing the surveys of techniques utilized by epilepsy surgical procedure facilities (e.g., Rausch, 1987; Snyder, Novelly, & Harris, 1990), there isn't basically nice heterogeneity within the equipment used in the course of Wada trying out to evaluate language and reminiscence services, yet there additionally appears a scarcity of consensus in regards to the theoretical assumptions, and maybe, even the ambitions of this procedure.

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Extra info for Amobarbital Effects and Lateralized Brain Function: The Wada Test

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The likelihood of amnesia following unilateral temporal lobectomy cannot be determined from the original studies. Nevertheless, Penfield & Milner's patients document the risk for post-resection memory impairment if contralateral temporal lobe dysfunction is also present, and patients with atypical language representation may invalidate the interpretation of standard neuropsychological evaluation. Less severe impairment in recent or materialspecific memory may remain a significant consideration in individuals who rely heavily on memory for their occupational success.

During drug effect of the Janguage dominant hemisphere, the pre-injection color was recalled during only 4/15 dominant hemisphere injections, number recalled in 4/15 cases, and sentence recalled in 0/12 cases. Following recovery, performance improved with 14/15 patients recalling the color, 12/15 patients recalling the number, and 10/12 patients recalling the sentence. Thus, sentence recall appeared most affected by the presence of linguistic disturbance. Following injection to the non-dominant side, the color was recalled following 12/14 injections, number recalled in 12/14 patients, and sentence recalled in 10/12 cases.

This type of nearly correct response, seen also with her temporal orientation, raises further concern regarding the etiology of her postoperative memory defIcit. Since there was no post-mortem examination, the case was tested prior to CT and MRI, and a signifIcant psychiatric history exists, it is difficult to attribute the post surgical memory defIcit to a single cause. Conclusions. M. Memory impairment was described during the immediate post-surgical recovery, but often, memory returned to normal or was only subjectively decreased with longer follow-up.

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